A modular hydrogel system with independent control of bioadhesion, fibrosis, and stiffness
Hydrogels that adhere to biological tissues and resist fibrosis are required to provide both optimal functionality and appropriate stiffness on diverse soft tissues to achieve therapeutic efficacy and biocompatibility. However, their performance is often limited by an intrinsic trade-off between functionality and stiffness. Through the incorporation of polymer brush coatings, we develop a modular hydrogel system to enable independent control of functionality and stiffness. By tailoring coating chemistry, coating thickness, and hydrogel network topology, we obtain consistent bioadhesion (~100 joules per square meter) and fibrosis suppression across the full stiffness range of soft tissues (1 kilopascal to 1 megapascal). Using this approach, we design a hydrogel that can maintain stable adhesion in vivo on a beating mouse heart and a hydrogel with no fibrotic capsule in immunocompetent mice over 40 days. This modular system offers a customizable approach for designing functional implants with tailored mechanical properties.
Authors
- Rajith S. Manan (ORCID: https://orcid.org/0000-0001-7081-0138)
- Daniel G. Anderson (ORCID: https://orcid.org/0000-0001-5629-4798)
- Steffen Pabel (ORCID: https://orcid.org/0009-0000-1121-4889)
- Róbert Langer (ORCID: https://orcid.org/0000-0003-4255-0492)
- Jiawei Yang (ORCID: https://orcid.org/0000-0003-2446-0004)
- Yichao Zhao (ORCID: https://orcid.org/0000-0002-2884-8105)
- William J. Jeang (ORCID: https://orcid.org/0000-0002-5401-8535)
- Matthias Nahrendorf (ORCID: https://orcid.org/0000-0002-4021-1887)
- Bryan M. Wong (ORCID: https://orcid.org/0000-0002-3909-4687)
Institutions
- Worcester Polytechnic Institute (US)
- Boston Children's Hospital (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
- Boston Children's Museum (US)
- Center for Systems Biology (US)
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- Science Advances
- Published
- 2026-06-24
- DOI
- https://doi.org/10.1126/sciadv.aee3894
- Primary Topic
- Hydrogels: synthesis, properties, applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- Leona M. and Harry B. Helmsley Charitable Trust
- Juvenile Diabetes Research Foundation United Kingdom
- Deutsche Forschungsgemeinschaft
- National Institutes of Health
- National Cancer Institute