LncRNA NRIR Promotes Myocardial Injury Through the miR-515-5p/SLC40A1 Axis: Diagnostic and Prognostic Implications in Acute Myocardial Infarction
Negative regulator of interferon response (NRIR) expression was upregulated in patients with acute myocardial infarction (AMI) and in oxygen-glucose deprivation-induced cardiomyocytes.Elevated NRIR levels were associated with progression of AMI and poor prognosis, indicating its potential as a diagnostic and prognostic biomarker for AMI.Mechanistically, NRIR aggravates cardiomyocyte injury by modulating the miR-515-5p/SLC40A1 axis, leading to enhanced oxidative stress, mitochondrial dysfunction, and apoptosis.These findings suggest that targeting the NRIR/miR-515-5p/SLC40A1 axis may offer a novel therapeutic strategy for alleviating myocardial injury and improving clinical outcomes in AMI.
Authors
- Peirong Zhang (ORCID: https://orcid.org/0000-0001-5597-9752)
- Yanwei Cheng (ORCID: https://orcid.org/0000-0002-8773-9259)
- Tai Dou (ORCID: https://orcid.org/0009-0006-2337-6280)
- Lijun Xu (ORCID: https://orcid.org/0009-0003-6120-9895)
- Yuling Ma (ORCID: https://orcid.org/0009-0006-6466-0245)
- Peng Wang (ORCID: https://orcid.org/0009-0005-3829-1776)
Institutions
- Zhengzhou Jinshui District General Hospital (CN)
- Henan Provincial People's Hospital (CN)
Publication Details
- Journal
- Korean Circulation Journal
- Published
- 2026-06-24
- DOI
- https://doi.org/10.4070/kcj.2025.0472
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00