Regulating Host–Guest Interactions in a Mixed-Ligand Metal–Organic Framework for Short-Chain PFAS Detection

exhibits a sensitive and visual "turn-on" fluorescence response toward PFHxA in aqueous media. Mechanism studies revealed that the synergistic effect of hydrophobic and electrostatic interactions, regulated by the ratio of mixed ligands, contributes to the strong affinity between the sensing material and PFHxA. This work provides a finely regulated system for the facile and rapid detection of PFAS in water and reveals the key structural factors governing the effective sensing performance of MOF-based materials.