Preliminary Clinical Experience in the Treatment of Recalcitrant Plantar Heel Pain With Stromal Vascular Fraction: Short- and Long-Term Findings From a Case Series

This case series aims to report preliminary clinical experience in treating plantar heel pain with stromal vascular fraction (SVF) derived from adipose tissue. Four representative cases are presented. The patients were treated with a single injection of stromal vascular fraction obtained through mechanical processing of each patient’s adipose tissue. Each patient was followed up for up to 360 days after treatment. Pain was evaluated with the visual analog scale (VAS), and ultrasound (US) examination was performed at baseline and six months after treatment. A significant improvement in the VAS scale was observed in all patients within seven days. This improvement was maintained for up to 360 days. This is the first report on the treatment of plantar heel pain with SVF. These initial cases showed promising results in terms of fast and durable pain resolution. A larger clinical series is currently underway to confirm these preliminary data.