Advancing global genomic equity: making a case for national genome projects in Africa

Genomic data hold transformative potential for healthcare. Despite their unparalleled genetic diversity, African populations remain underrepresented in global genomics research, contributing to poorer health outcomes both within Africa and globally. Political, financial, and social challenges hinder progress, and therefore advocacy for public understanding of genomics, addressing social stigma, and aligning initiatives with national policies are critical steps forward. Africa hosts a large pool of highly skilled scientists and laboratories with DNA analysis capacity to harness for human genetics research and service provision, presenting opportunities for growth and innovation. This article highlights progress in African genomics, emphasizes the importance of equity, and proposes actionable steps for prioritizing, funding, and implementing national genome projects. It is a call to action. Genomic data could transform healthcare, but African populations are underrepresented, currently limiting benefits. Here the authors highlight how addressing political, financial, and social barriers and advancing equitable national genome projects is essential.