Pd(II)-Catalyzed Oxidative Annulation of Alkenes toward Isoxazoline <i>N</i> -Oxides
A Pd(II)-catalyzed [3 + 2] annulation of alkenyl amides and nitroalkanes is described. The method furnishes intricately functionalized isoxazoline N- oxide products in a single step from simple starting materials, enabling expedient access to this underexplored class of heterocycles. With internal and α-functionalized olefins, the reaction proceeds with high diastereoselectivity, providing controlled entry into isoxazoline N- oxides with multiple stereogenic centers.
Authors
- Davin G. Piercey (ORCID: https://orcid.org/0000-0003-3732-9371)
- Keary M. Engle (ORCID: https://orcid.org/0000-0003-2767-6556)
- Nicholas F. Scherschel (ORCID: https://orcid.org/0009-0006-8652-0649)
- Yilin Cao (ORCID: https://orcid.org/0000-0002-4964-0565)
- Hui‐Qi Ni (ORCID: https://orcid.org/0009-0006-4848-638X)
- Shenghua Yang (ORCID: https://orcid.org/0000-0001-9190-6892)
- Yiyao Hu (ORCID: https://orcid.org/0009-0005-0731-3602)
- Lan Zhu
Institutions
- Scripps Research Institute (US)
- Purdue University West Lafayette (US)
- Applied Energetics (United States) (US)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-06-24
- DOI
- https://doi.org/10.1021/acs.orglett.6c01696
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of General Medical Sciences