Enhancing scar appearance: Results from a cosmetic clinical study on dexpanthenol‐containing silicone gel and massage ball in adults and children

OBJECTIVE: To evaluate changes in scar appearance and tolerability associated with 8 weeks of use of a test product comprising a topical dexpanthenol-containing silicone gel with an integrated massage ball in individuals with existing immature hypertrophic scars. METHODS: This was a prospective monocentric, open-label, exploratory, single-arm, in-use study with intra-individual comparison, which enrolled 55 participants with hypertrophic scars aged 1-12 months. Participants massaged the scar with the test product's integrated massage ball prior to applying the dexpanthenol-containing silicone gel twice daily for 8 weeks. Scar appearance was assessed at baseline and at Day 57 using the Patient and Observer Scar Assessment Scale (POSAS), supported by clinical photography, instrumental skin measurements and a participant questionnaire. RESULTS: After 8 weeks, a statistically significant improvement in overall scar appearance was observed, as reflected by a reduction in the total POSAS score. Improvements were reported by both observers and participants across multiple scar parameters, including thickness, pliability and relief. Instrumental assessments supported these findings, including a reduction in scar thickness. The product was well tolerated, with no product-related adverse reactions, and participants reported high overall satisfaction. CONCLUSION: Under the study conditions, the test product was associated with improvements in the appearance of existing immature hypertrophic scars and was well tolerated in a population comprising both adults and children. These findings support its potential utility in topical scar management, including in pediatric populations.