Performance of Survival Prediction Tools in Patients With Gastrointestinal Stromal Tumors: A Systematic Review and Meta‐Analysis
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. We conducted a systematic review and meta-analysis of studies that developed, validated, or updated clinical prognostic tools to predict survival in adults with primary GIST, identifying 47 eligible studies (38 development and 9 validation studies). Meta-analyses were performed to assess performance in external validation cohorts. The MSKCC nomogram was most frequently validated, with a pooled C-statistic of 0.78 for recurrence-free survival.
Authors
- Neill K. J. Adhikari (ORCID: https://orcid.org/0000-0003-4038-5382)
- A A Mahar
- Amy T. Hsu (ORCID: https://orcid.org/0000-0002-2747-4121)
- Alice Zhu (ORCID: https://orcid.org/0000-0001-5387-5917)
- Natalie Coburn
- Chloe Wong
- Ka Yan Ip
- Julie Hallet
Institutions
- Sunnybrook Health Science Centre (CA)
- University of Ottawa (CA)
- University of Toronto (CA)
- Queen's University (CA)
- Ottawa Hospital (CA)
- Health Sciences Centre (CA)
- Bruyère (CA)
- Institute for Clinical Evaluative Sciences (CA)
- Ottawa Hospital Research Institute (CA)
Publication Details
- Journal
- Journal of Surgical Oncology
- Published
- 2026-06-18
- DOI
- https://doi.org/10.1002/jso.70303
- Primary Topic
- Gastrointestinal Tumor Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00