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On the Cover: John et al. report that minocycline treatment decreases chronic mechanical hypersensitivity in male – but not female – sickle cell disease mice. The authors go on to determine that observed sex differences result from sexspecific minocycline effects on spinal microgliosis and microbiome composition. This illustration reimagines the findings of this manuscript as the classic arcade claw machine; a microglial shaped “claw” is being maneuvered to capture the bacteria-shaped prizes. For more information, see p. 1683.