Greener synthesis of novel 5-pyrazolyl-pyridine-3-carbonitriles using recyclable Fe ₃ O ₄ @sP-VNL-TGA magnetic nanocomposite

Fe3O4@SP-VNL-TGA MNCs (bis(thioglycolic acid)-vanillin(2,2’-(((4-hydroxy-3-methoxyphenyl)methylene)bis(sulfanediyl))diacetic acid)‐functionalized silica‐coated Fe3O4 magnetic nanocomposite) were synthesized and characterized by FE-SEM, TEM, VSM, XRD, TGA, EDX, and FT-IR. Fe3O4@SP-VNL-TGA offer an eco-friendly method for the preparation of novel 5-pyrazolyl-pyridine-3-carbonitriles through one-pot reaction of the corresponding pyrazolyl carbaldehydes, various acetophenones, malononitrile, and ammonium acetate. The compounds were obtained in high yields and short reaction times. The catalyst was effectively recovered and reused for six cycles with nearly the same activity. The structures of the synthesized 5-pyrazolyl-pyridine-3-carbonitriles were confirmed by 1H and 13C NMR spectroscopy, mass spectroscopy, FT-IR and elemental analyses.