ST-segment elevation myocardial infarction as the first manifestation of JAK2-positive myeloproliferative neoplasm in a young man

A 33-year-old man, an active smoker with no hypertension or diabetes, no familial premature coronary disease, and a body mass index of 25.0 kg/m 2 , presented with acute chest pain and electrocardiographic features of anterior ST-segment elevation myocardial infarction.He denied recent infection, stressful events, or use of psychoactive substances.Echocardiography showed anterior wall hypokinesis with an ejection fraction of 50%.Urgent coronary angiography showed ostial occlusion of the left anterior descending artery (LAD; Supplementary material, Video S1).Optical coherence tomography (OCT) demonstrated a large intraluminal thrombus, causing severe luminal compromise, without definite plaque rupture,