Coaxial Hybrid Ionization–Mass Cytometry for High-Throughput and High-Coverage Single-Cell Metabolomics
]pyrene (BaP) - a prototypical polycyclic aromatic hydrocarbon (PAH) - induced metabolic perturbations at single-cell resolution in HepG2 cells. The uptake and clearance curve of intracellular BaP as well as the dynamic metabolic trajectory across exposure time were successfully resolved, initially characterizing the coupling relationship between exogenous exposure and endogenous metabolic status.
Authors
- Hongwei Hou (ORCID: https://orcid.org/0000-0001-9389-4928)
- Yu Bai (ORCID: https://orcid.org/0000-0003-1542-0297)
- Yu Zhang (ORCID: https://orcid.org/0000-0002-2358-0904)
- Shaojie Qin (ORCID: https://orcid.org/0009-0008-9693-3898)
- Qi Li (ORCID: https://orcid.org/0000-0001-8776-8730)
- Mingxuan Li
- Mingying Shi
- Lili Cui
- Huan Chen
Institutions
- Peking University (CN)
- Beijing National Laboratory for Molecular Sciences (CN)
- Beijing Academy of Science and Technology (CN)
Publication Details
- Journal
- Analytical Chemistry
- Published
- 2026-06-18
- DOI
- https://doi.org/10.1021/acs.analchem.6c02532
- Primary Topic
- bioluminescence and chemiluminescence research
- Type
- article
- Field-Weighted Citation Impact
- 0.00