Decisional reversal after antidepressant initiation: The role of early subjective experience in clinical practice

ObjectiveTo discuss how early subjective experiences following antidepressant initiation may influence treatment continuation and contribute to decisional reversal.ConclusionsEarly activating effects, particularly after selective serotonin reuptake inhibitor (SSRI) initiation, may function as interpretative signals leading patients to reconsider treatment initiation. Anticipatory guidance and early follow-up may help sustain adherence.