Glomeruloid haemangioma in Erdheim–Chester disease: An atypical skin manifestation associated with elevated vascular endothelial growth factor‐A levels
Glomeruloid haemangiomas and extensive angiomas occurred in a small subset of Erdheim-Chester disease patients, all showing markedly elevated vascular endothelial growth factor-A (VEGF-A) levels despite the absence of POEMS (polyneuropathy, organomegaly, M-spike, and skin disease) syndrome. Molecular analyses demonstrated mitogen-activated protein kinase (MAPK)-activated histiocytes without endothelial mutations, supporting a paracrine VEGF-A-driven angiogenesis mechanism underlying these atypical cutaneous lesions.
Authors
- Félix Blaison
- Francesco Pegoraro (ORCID: https://orcid.org/0000-0002-4954-5744)
- Jean‐François Emile (ORCID: https://orcid.org/0000-0002-6073-4466)
- Paul Legendre (ORCID: https://orcid.org/0000-0003-2787-5491)
- Matthias Papo (ORCID: https://orcid.org/0000-0003-3389-9473)
- Julien Haroche (ORCID: https://orcid.org/0009-0003-9794-1316)
- Valentin Carado
- Augusto Vaglio
- Martin Caretti
- Aubriot Lorton Marie Helene
- Jerome Razanamahery
Institutions
- Université de Bordeaux (FR)
- Sorbonne Université (FR)
- Bordeaux Population Health (FR)
- Pitié-Salpêtrière Hospital (FR)
- Centre Hospitalier du Mans (FR)
- Hôpital Ambroise-Paré (FR)
- Maison des Sciences sociales et des Humanités de Dijon (FR)
- University of Florence (IT)
Publication Details
- Journal
- British Journal of Haematology
- Published
- 2026-06-19
- DOI
- https://doi.org/10.1111/bjh.70627
- Primary Topic
- Histiocytic Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00