LincRNA-Cox2 in Inflammation: Regulatory Networks, Experimental Insights, and Future Directions

LincRNA-Cox2 has emerged as a functionally significant long intergenic non-coding RNA in the regulation of inflammatory responses, attracting increasing attention for its diverse roles in immune signaling and gene expression control. This review begins with a brief introduction to the biological importance of inflammation and the expanding relevance of long non-coding RNAs in immunoregulation. This review then examines the broader role of lncRNAs in the inflammatory response, establishing the conceptual framework necessary to understand the specific contribution of LincRNA-Cox2. Subsequently, it addresses the discovery, biological characteristics, and expression dynamics of LincRNA-Cox2, followed by a detailed discussion of its mechanistic roles in inflammation. In addition, the review synthesizes major experimental findings derived from both in vitro studies and in vivo models, highlighting how current evidence has advanced understanding of LincRNA-Cox2-mediated immune regulation. Finally, this review discusses the major conclusions emerging from the field and outlines future directions for research, with particular emphasis on unresolved mechanistic questions and translational potential. This review aims to provide a coherent perspective on LincRNA-Cox2 as an important regulatory molecule in inflammatory biology and a promising target for future investigation.