Towards an ecosystem of clinical decision support tools for precision cancer medicine

Molecular tumor boards are supported by clinical decision support system (CDSS) tools for the interpretation of complex molecular data towards personalized treatments. Current CDSS tools are genomics-focused and characterized by tight couplings between data ingestion, guideline-based reasoning logic and curated knowledgebases. Next-generation CDSS solutions should integrate multimodal data and learn from outcomes in an interoperable ecosystem, leveraging explainable, trustworthy output from AI models through rigorous clinical validation processes.

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Publication Details

Journal
npj Precision Oncology
Published
2026-06-17
DOI
https://doi.org/10.1038/s41698-026-01551-6
Primary Topic
Cancer Genomics and Diagnostics
Type
article
Field-Weighted Citation Impact
0.00

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Towards an ecosystem of clinical decision support tools for precision cancer medicine

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npj Precision Oncology
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Towards an ecosystem of clinical decision support tools for precision cancer medicine

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article en

Abstract

Molecular tumor boards are supported by clinical decision support system (CDSS) tools for the interpretation of complex molecular data towards personalized treatments. Current CDSS tools are genomics-focused and characterized by tight couplings between data ingestion, guideline-based reasoning logic and curated knowledgebases. Next-generation CDSS solutions should integrate multimodal data and learn from outcomes in an interoperable ecosystem, leveraging explainable, trustworthy output from AI models through rigorous clinical validation processes.

npj Precision Oncology
Oslo University Hospital (NO), Norwegian Institute of Public Health (NO), Karolinska University Hospital (SE), University of Helsinki (FI), Vilnius University (LT), Stockholm School of Economics (SE), University of Oslo (NO), Heidelberg University (DE), Leiden University Medical Center (NL), Science for Life Laboratory (SE), Helsinki University Hospital (FI), University Hospital Heidelberg (DE), Tartu University Hospital (EE), Copenhagen University Hospital (DK), Rigshospitalet (DK), Karolinska Institutet (SE), Centre Léon Bérard (FR), IPO Porto (PT), National Institute of Oncology (HU), Vall d'Hebron Hospital Universitari (ES), Skåne University Hospital (SE), Erasmus MC Cancer Institute (NL), The Maria Sklodowska-Curie National Research Institute of Oncology (PL), National Cancer Institute (LT), Hartwig Medical Foundation (NL), Vall d'Hebron Institute of Oncology (ES), University of Tartu (EE), European Institute of Oncology (IT), University of Split (HR)
Swedish Cancer Foundation, European Commission, Vetenskapsrådet, Norges Forskningsråd, Radiumhemmets Forskningsfonder
Openalex Percentile: Top 8%
Cancer Genomics and Diagnostics
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