Towards an ecosystem of clinical decision support tools for precision cancer medicine
Molecular tumor boards are supported by clinical decision support system (CDSS) tools for the interpretation of complex molecular data towards personalized treatments. Current CDSS tools are genomics-focused and characterized by tight couplings between data ingestion, guideline-based reasoning logic and curated knowledgebases. Next-generation CDSS solutions should integrate multimodal data and learn from outcomes in an interoperable ecosystem, leveraging explainable, trustworthy output from AI models through rigorous clinical validation processes.
Authors
- Knut B. Smeland (ORCID: https://orcid.org/0000-0002-9832-4032)
- Ragnhild Sørum Falk (ORCID: https://orcid.org/0000-0001-8398-3492)
- Giuseppe Curigliano (ORCID: https://orcid.org/0000-0003-1781-2518)
- Martin Højgaard (ORCID: https://orcid.org/0000-0003-1850-535X)
- Rasa Sabaliauskaitė (ORCID: https://orcid.org/0000-0002-3465-3558)
- Paola Zagami (ORCID: https://orcid.org/0000-0002-2687-6436)
- Birutė Brasiūnienė (ORCID: https://orcid.org/0000-0002-7097-1131)
- Katriina Peltola (ORCID: https://orcid.org/0000-0002-3007-193X)
- David Tamborero (ORCID: https://orcid.org/0000-0002-7218-2806)
- Eline Aas (ORCID: https://orcid.org/0000-0002-9878-6165)
- Egbert F. Smit (ORCID: https://orcid.org/0000-0002-7329-6995)
- Tiina Kahre (ORCID: https://orcid.org/0009-0007-4399-354X)
- Simon Ekman (ORCID: https://orcid.org/0000-0002-8343-6226)
- Richard Rosenquist (ORCID: https://orcid.org/0000-0002-0211-8788)
- Edita Baltruškevičienė (ORCID: https://orcid.org/0000-0002-5089-9136)
- Mika Mustonen (ORCID: https://orcid.org/0000-0002-7899-0564)
- Hans A. J. Gelderblom (ORCID: https://orcid.org/0000-0001-9270-8636)
- Albrecht Stenzinger (ORCID: https://orcid.org/0000-0003-1001-103X)
- Júlio Oliveira (ORCID: https://orcid.org/0000-0002-9576-3486)
- Sigve Nakken (ORCID: https://orcid.org/0000-0001-8468-2050)
- Paul Roepman (ORCID: https://orcid.org/0000-0003-1566-0258)
- Vigdis Nygaard (ORCID: https://orcid.org/0000-0001-8150-3731)
- Alba López Rioja (ORCID: https://orcid.org/0000-0002-2893-7087)
- Anni Lepland (ORCID: https://orcid.org/0000-0002-6448-4847)
- Elena Chavarria (ORCID: https://orcid.org/0009-0008-3182-8309)
- Anders Edsjö (ORCID: https://orcid.org/0000-0001-8783-8284)
- Ebba Hallersjö Hult (ORCID: https://orcid.org/0009-0005-7247-9510)
- Soemeya F. Haj Mohammad (ORCID: https://orcid.org/0000-0002-7339-1714)
- Kristoffer Staal Rohrberg (ORCID: https://orcid.org/0000-0002-5448-9003)
- Iwona Ługowska (ORCID: https://orcid.org/0000-0001-9511-178X)
- Jean‐Yves Blay (ORCID: https://orcid.org/0000-0001-7190-120X)
- R. Rosenquist
- Kjetil Taskén (ORCID: https://orcid.org/0000-0003-2841-4697)
- Hege Giercksky Russnes (ORCID: https://orcid.org/0000-0001-8724-1891)
- Henriett Butz (ORCID: https://orcid.org/0000-0003-1664-409X)
- Janne Lehtiö (ORCID: https://orcid.org/0000-0002-8100-9562)
- Bettina Ryll (ORCID: https://orcid.org/0000-0002-2652-8474)
- Åslaug Helland (ORCID: https://orcid.org/0000-0002-5520-0275)
- Rui Henrique (ORCID: https://orcid.org/0000-0003-3171-4666)
- Elena Garralda (ORCID: https://orcid.org/0000-0002-4412-7842)
- Daniel Kazdal (ORCID: https://orcid.org/0000-0001-8187-3281)
- Sigmund Brabrand (ORCID: https://orcid.org/0009-0006-3218-933X)
- Tormod Kyrre Guren (ORCID: https://orcid.org/0000-0001-6471-2072)
- Eduard Vrdoljak (ORCID: https://orcid.org/0000-0002-2908-3474)
- Hans Timmer (ORCID: https://orcid.org/0009-0002-3822-7326)
- Attila Patócs (ORCID: https://orcid.org/0000-0001-7506-674X)
- Ulrik Lassen (ORCID: https://orcid.org/0000-0002-3865-4574)
- Loïc Verlingue (ORCID: https://orcid.org/0000-0002-5694-4022)
- Irene Braña (ORCID: https://orcid.org/0000-0002-1068-9601)
- Eivind J. Hovig (ORCID: https://orcid.org/0000-0002-9103-1077)
- Anu Planken (ORCID: https://orcid.org/0000-0003-4553-1852)
- Sonata Jarmalaitė (ORCID: https://orcid.org/0000-0003-3719-0891)
- Beatrice Mainoli (ORCID: https://orcid.org/0000-0002-5295-4346)
- Henk M.W. Verheul (ORCID: https://orcid.org/0000-0001-5981-922X)
- Sahar Barjesteh van Waalwijk van Doorn-Khosrovani (ORCID: https://orcid.org/0000-0003-1239-9867)
- Antonio Marra (ORCID: https://orcid.org/0000-0002-7310-7824)
- Gro Live Fagereng (ORCID: https://orcid.org/0000-0003-2600-6606)
- Vince Kornél Grolmusz (ORCID: https://orcid.org/0000-0002-5677-895X)
- Elisa Bjørgo (ORCID: https://orcid.org/0000-0003-3877-7248)
- Hovig Eivind
- T Juslin
- Kadri Toome (ORCID: https://orcid.org/0009-0007-5206-5737)
- Tina Kringelbach
- Hege G. Russnes
- Sen Zhao
- Izabela Agnieszczak (ORCID: https://orcid.org/0009-0002-1829-3094)
- Kadri Rekker (ORCID: https://orcid.org/0009-0001-4548-5756)
- Agnieszka Janowska (ORCID: https://orcid.org/0009-0006-2077-1082)
Institutions
- Oslo University Hospital (NO)
- Norwegian Institute of Public Health (NO)
- Karolinska University Hospital (SE)
- University of Helsinki (FI)
- Vilnius University (LT)
- Stockholm School of Economics (SE)
- University of Oslo (NO)
- Heidelberg University (DE)
- Leiden University Medical Center (NL)
- Science for Life Laboratory (SE)
- Helsinki University Hospital (FI)
- University Hospital Heidelberg (DE)
- Tartu University Hospital (EE)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Karolinska Institutet (SE)
- Centre Léon Bérard (FR)
- IPO Porto (PT)
- National Institute of Oncology (HU)
- Vall d'Hebron Hospital Universitari (ES)
- Skåne University Hospital (SE)
- Erasmus MC Cancer Institute (NL)
- The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
- National Cancer Institute (LT)
- Hartwig Medical Foundation (NL)
- Vall d'Hebron Institute of Oncology (ES)
- University of Tartu (EE)
- European Institute of Oncology (IT)
- University of Split (HR)
Publication Details
- Journal
- npj Precision Oncology
- Published
- 2026-06-17
- DOI
- https://doi.org/10.1038/s41698-026-01551-6
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Swedish Cancer Foundation
- European Commission
- Vetenskapsrådet
- Norges Forskningsråd
- Radiumhemmets Forskningsfonder