Regulating the Nano–Bio Interface: Converging Electrochemical and Photonic Biosensing for Wearable Diagnostics

The development of wearable biosensors has accelerated due to the combination of nanomaterials, integrative electronics, and miniaturized transduction mechanisms, enabling continuous monitoring of physiological and environmental markers. Electrochemical and photonic modalities have been shown to exhibit complementary capabilities in wearable applications, with each offering distinct advantages in sensitivity, selectivity, miniaturization, and power efficiency. Beyond single-modality functionality, the next generation of wearable diagnostics integrates electrochemical and optical transduction within the same platforms. In this short review, we examine the physical and functional demands of such convergence in wearable systems, highlighting model electrochemical systems, such as textile-integrated wound monitoring and hormone sensors, and how optical modalities provide orthogonal observables of interfacial and biochemical conditions. We further explore new emerging device architectures that leverage electrochemical and optical interrogation to generate robust, information-rich data sets, supporting long-term, real-world deployment of wearable diagnostic technologies for personalized healthcare and continuous monitoring applications.