Large language models for acute coronary syndrome triage at first medical contact in emergency departments
Acute coronary syndrome triage at first medical contact begins with patient narratives, while definitive diagnosis often requires waiting for cardiac troponin or electrocardiogram results. We developed TriageMaster-70B, a large language model using only patient narratives and vital signs for the triage. In 16,428 retrospective and 512 prospective cases, it showed high sensitivity, with per-case processing 39% faster than independent retrospective cardiologist review. These findings suggest TriageMaster-70B may support rapid, accurate, and interpretable triage in emergency departments. Clinical trial registration: ClinicalTrials.gov NCT06493175; first posted September 20, 2024.
Authors
- X G Wang
- Mengdan Miao (ORCID: https://orcid.org/0000-0003-2180-1168)
- Hongxing Luo (ORCID: https://orcid.org/0000-0001-5721-6302)
- Jun Lv (ORCID: https://orcid.org/0000-0001-7916-3870)
- Shuanli Xin (ORCID: https://orcid.org/0000-0003-4763-7036)
- Chuanjie Wu (ORCID: https://orcid.org/0000-0002-0494-416X)
- Jing Chen (ORCID: https://orcid.org/0000-0002-3297-9183)
- Ling Li (ORCID: https://orcid.org/0000-0002-1642-142X)
- Kuo Zhang (ORCID: https://orcid.org/0009-0004-2847-3325)
- Yuwei Wu (ORCID: https://orcid.org/0000-0003-4926-2530)
- Yi-Xiang Wang (ORCID: https://orcid.org/0000-0002-4021-4228)
- P. P. Li
- Wenyao Wang (ORCID: https://orcid.org/0000-0001-9897-2761)
- Mingqi Zheng
- Canqing Yu
- Xiangbin Meng
- Chunli Shao
- Da Liu
- Xiangyu Yan
- Guan Wang
- Hua Xu
Institutions
- Hebei Medical University (CN)
- King University (US)
- Handan College (CN)
- Oslo University Hospital (NO)
- Tianjin University (CN)
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Hong Kong University of Science and Technology (HK)
- Peking University (CN)
- Maastricht University (NL)
- Tsinghua–Berkeley Shenzhen Institute (CN)
- Peng Cheng Laboratory (CN)
- Peking University Third Hospital (CN)
- Shanghai Institute of Hematology (CN)
- Beijing Hua Xin Hospital (CN)
- First Affiliated Hospital of Hebei Medical University (CN)
- Fu Wai Hospital (CN)
- Shenzhen Third People’s Hospital (CN)
Publication Details
- Journal
- npj Digital Medicine
- Published
- 2026-06-17
- DOI
- https://doi.org/10.1038/s41746-026-02904-y
- Primary Topic
- Emergency and Acute Care Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Capital Medical University
- Peking University
- Peking University Third Hospital
- Hebei Medical University
- National Health Commission of the People's Republic of China
- National Key Research and Development Program of China