Recent Advances in Synthesis and Applications of Fluorinated Sugars: A Mini Review

ABSTRACT Fluorinated sugars have emerged as powerful tools in glycoscience due to their wide‐ranging biological applications. However, the stereoselective installation of fluorine and subsequent glycosylation remain significant challenges, often complicated by competing rearrangement pathways. This mini review highlights recent advances in the synthesis of fluorinated sugars, encompassing chemical, enzymatic, and automated glycan assembly (AGA) approaches. Furthermore, it discusses the diverse applications of fluorinated carbohydrates in biological systems, including the use of 19 F NMR as a probe to study glycan–protein interactions, as enzyme inhibitors, and in vaccine development. Collectively, these advances underscore the growing importance of fluorinated sugars in expanding the toolkit of modern glycobiology and therapeutic research.