Outcome of treatment with trametinib in adults with histiocytic neoplasms in the United Kingdom
Trametinib (MEK inhibitor) shows efficacy in refractory and high-risk adult histiocytic neoplasms. At a median follow-up of 21.4 months, the clinical response rate was 81% (30/37) and the radiological response was 68% (25/37) (n = 37).
Authors
- Jagdish Adiyodi (ORCID: https://orcid.org/0000-0001-9736-4190)
- Hayder Hussein (ORCID: https://orcid.org/0000-0002-9502-2952)
- Philippa Kelsey (ORCID: https://orcid.org/0000-0001-7486-3552)
- Matthew Collin (ORCID: https://orcid.org/0000-0001-6585-9586)
- Talha Munir (ORCID: https://orcid.org/0000-0002-2901-0769)
- Trung Van Nguyen (ORCID: https://orcid.org/0000-0003-3363-5064)
- Rodothea Amerikanou (ORCID: https://orcid.org/0000-0001-6691-9210)
- Rui Zhao (ORCID: https://orcid.org/0000-0001-5208-1672)
- Satyen H. Gohil (ORCID: https://orcid.org/0000-0003-0484-991X)
- Jeffrey Smith (ORCID: https://orcid.org/0000-0001-9613-8976)
- Richard Adams
- Christopher McNamara
- Elizabeth Price
- Nikesh Chavda
- Kristian Bowles
- Alasdair Coles
Institutions
- University of East Anglia (GB)
- University Hospitals Birmingham NHS Foundation Trust (GB)
- University College London Hospitals NHS Foundation Trust (GB)
- Leeds Teaching Hospitals NHS Trust (GB)
- Norfolk and Norwich University Hospital (GB)
- Great Ormond Street Hospital for Children NHS Foundation Trust (GB)
- University Hospitals Bristol NHS Foundation Trust (GB)
- University Hospital of Wales (GB)
- Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
- Torbay Hospital (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- Clatterbridge Cancer Centre NHS Foundation Trust (GB)
- Queen Elizabeth Hospital (GB)
- Sheffield Teaching Hospitals NHS Foundation Trust (GB)
- Great Western Hospitals NHS Foundation Trust (GB)
- Torbay and South Devon NHS Foundation Trust (GB)
- Royal Blackburn Teaching Hospital (GB)
- University College London (GB)
- Newcastle University (GB)
Publication Details
- Journal
- British Journal of Haematology
- Published
- 2026-06-17
- DOI
- https://doi.org/10.1111/bjh.70617
- Primary Topic
- Histiocytic Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00