Outcome of treatment with trametinib in adults with histiocytic neoplasms in the United Kingdom

Trametinib (MEK inhibitor) shows efficacy in refractory and high-risk adult histiocytic neoplasms. At a median follow-up of 21.4 months, the clinical response rate was 81% (30/37) and the radiological response was 68% (25/37) (n = 37).

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Publication Details

Journal
British Journal of Haematology
Published
2026-06-17
DOI
https://doi.org/10.1111/bjh.70617
Primary Topic
Histiocytic Disorders and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Outcome of treatment with trametinib in adults with histiocytic neoplasms in the United Kingdom

Jagdish Adiyodi, Hayder Hussein, Philippa Kelsey, Matthew Collin et al.
British Journal of Haematology
Histiocytic Disorders and Treatments
article

Outcome of treatment with trametinib in adults with histiocytic neoplasms in the United Kingdom

Jagdish Adiyodi, Hayder Hussein, Philippa Kelsey, Matthew Collin, Talha Munir, Trung Van Nguyen, Rodothea Amerikanou, Rui Zhao, Satyen H. Gohil, Jeffrey Smith, Richard Adams, Christopher McNamara, Elizabeth Price, Nikesh Chavda, Kristian Bowles, Alasdair Coles
article en

Abstract

Trametinib (MEK inhibitor) shows efficacy in refractory and high-risk adult histiocytic neoplasms. At a median follow-up of 21.4 months, the clinical response rate was 81% (30/37) and the radiological response was 68% (25/37) (n = 37).

British Journal of Haematology
University of East Anglia (GB), University Hospitals Birmingham NHS Foundation Trust (GB), University College London Hospitals NHS Foundation Trust (GB), Leeds Teaching Hospitals NHS Trust (GB), Norfolk and Norwich University Hospital (GB), Great Ormond Street Hospital for Children NHS Foundation Trust (GB), University Hospitals Bristol NHS Foundation Trust (GB), University Hospital of Wales (GB), Newcastle upon Tyne Hospitals NHS Foundation Trust (GB), Torbay Hospital (GB), Cambridge University Hospitals NHS Foundation Trust (GB), Clatterbridge Cancer Centre NHS Foundation Trust (GB), Queen Elizabeth Hospital (GB), Sheffield Teaching Hospitals NHS Foundation Trust (GB), Great Western Hospitals NHS Foundation Trust (GB), Torbay and South Devon NHS Foundation Trust (GB), Royal Blackburn Teaching Hospital (GB), University College London (GB), Newcastle University (GB)
Good health and well-being
Openalex Percentile: Top 7%
Histiocytic Disorders and Treatments
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