The Network Model of Mentalization, Social Vulnerability, and the Self in Autism: A Comparison With Neurotypical Adults

Autism spectrum disorder (ASD) is characterized by alterations in social understanding and self-related experience that overlap with broader dimensions of psychosocial vulnerability. These domains are tightly interconnected, motivating the use of analytic approaches that can capture their organization as complex associations rather than as isolated dimensions. We applied network analysis to autistic adults (N = 156) and demographically matched neurotypical controls (N = 454). Gaussian graphical models were estimated using sum scores of psychosocial constructs, and networks were compared using centrality metrics and the network comparison test. Compared to neurotypical participants, autistic individuals showed higher levels of psychosocial difficulties and lower global network strength. Mentalization emerged as a central node in both groups, while autistic traits were more central in the neurotypical network and trait anxiety showed relatively higher centrality in the ASD network. These findings suggest that psychosocial vulnerability in autism is characterized by a distinct and less integrated network organization, with mentalization playing a central role across groups and anxiety showing a relatively greater centrality in ASD. Network-based approaches may therefore help identify mechanism-relevant targets for intervention and refine dimensional models of social and self-related functioning in autism.