A Cathepsin <i>B</i> -Cleavable Self-Immolative Linker for the Delivery of Hydroxyl-Containing Payloads in Antibody–Drug Conjugates
. Collectively, this work establishes a versatile and generalizable linker strategy that expands the accessible payload space of ADCs and enables efficient, controlled delivery of hydroxyl-containing payloads, highlighting its potential for next-generation ADC development.
Authors
- Lizhe Bai
- Y W Li
- Wei Lü (ORCID: https://orcid.org/0000-0003-3041-9200)
- Xuzhuo Li
- Mengyuan Ding
- Shulei Zhu (ORCID: https://orcid.org/0000-0002-9747-2105)
- Yingxin Lu
- Xing Jiang
- Xiaomei Li
- Yue Guo
Institutions
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Materia Medica (CN)
- Drug Discovery Laboratory (Norway) (NO)
- State Key Laboratory of Drug Research
- East China Normal University (CN)
Publication Details
- Journal
- Bioconjugate Chemistry
- Published
- 2026-06-17
- DOI
- https://doi.org/10.1021/acs.bioconjchem.6c00121
- Primary Topic
- HER2/EGFR in Cancer Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Shanghai Rising-Star Program
- National Science and Technology Major Project