Electrochemically Enabled Sulfenylation of Imidazo[1,2- <i>a</i> ]pyridines Using Sodium Sulfinates
An electrochemical method for the C–H sulfenylation of imidazo[1,2- a ]pyridines has been developed, employing sodium sulfinates as odorless sulfenylation reagents. This approach provides efficient access to a range of C-3-sulfenated imidazo[1,2- a ]pyridines in moderate to good yields. The reaction proceeds smoothly under electrochemical conditions without the need for external chemical oxidants and exhibits a broad substrate scope, which offers a promising new strategy for C–S bond formation using odorless sulfenylation reagents.
Authors
- Y M Li
- Jiusi Yang
- Jiasheng Wang (ORCID: https://orcid.org/0000-0001-6519-4318)
- Tingting Lu (ORCID: https://orcid.org/0000-0002-2356-2714)
- Peng Qian (ORCID: https://orcid.org/0000-0002-1428-7028)
- Wenxuan Zhan
- Hailong Hu
- Lexuan Zhang
- Keren Du
- Tianjing Sun
Institutions
- Fuyang Normal University (CN)
- Anhui University of Science and Technology (CN)
- Anhui Medical University (CN)
- China Tobacco (CN)
- Biomass Technology Group (Netherlands) (NL)
- First Affiliated Hospital of Anhui Medical University (CN)
- Xiamen Tobacco Industry (China) (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-06-17
- DOI
- https://doi.org/10.1021/acs.joc.6c00839
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Anhui Provincial Department of Education
- Fuyang Normal University