A Multicomponent Chemistry for the Incorporation of <i>N</i> -Sulfonylguanidines into DNA-Encoded Libraries

To incorporate the N -sulfonylguanidine chemotype into DNA-encoded libraries (DELs), a cobalt-promoted, DNA-compatible N -sulfonylguanidine formation method has been developed. This method utilizes DNA-conjugated sulfonyl azides, isonitriles, and amines as readily accessible building blocks to enable modular, high-yielding synthesis of structurally diverse N -sulfonylguanidines, a privileged scaffold widely represented in biologically active small molecules.