Primary left atrial spindle cell sarcoma with low-grade malignant features mimicking recurrent myxoma: a case report

Primary cardiac spindle cell sarcoma is extremely rare, with atypical clinical manifestations and imaging features. This case report details a 54-year-old female patient with a primary cardiac spindle cell sarcoma of the left atrium, initially thought to represent a recurrent cardiac myxoma. Despite utilizing multiple imaging techniques, the patient's complex clinical history complicated the diagnostic process, and the correct diagnosis was established after surgical resection and pathological evaluation. This case highlights the diagnostic pitfalls associated with presumed recurrent cardiac myxomas and underscores the importance of careful pathological assessment and long-term surveillance, even in tumors with low-grade malignant features.

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Publication Details

Journal
Journal of Cardiothoracic Surgery
Published
2026-06-18
DOI
https://doi.org/10.1186/s13019-026-03980-7
Primary Topic
Cardiac tumors and thrombi
Type
article
Field-Weighted Citation Impact
0.00
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article

Primary left atrial spindle cell sarcoma with low-grade malignant features mimicking recurrent myxoma: a case report

D G Liu, Weiwei Li, Fengjuan Yao, Jing-wei Zhang et al.
Journal of Cardiothoracic Surgery
Cardiac tumors and thrombi
article

Primary left atrial spindle cell sarcoma with low-grade malignant features mimicking recurrent myxoma: a case report

D G Liu, Weiwei Li, Fengjuan Yao, Jing-wei Zhang, Yi Wang
article en

Abstract

Primary cardiac spindle cell sarcoma is extremely rare, with atypical clinical manifestations and imaging features. This case report details a 54-year-old female patient with a primary cardiac spindle cell sarcoma of the left atrium, initially thought to represent a recurrent cardiac myxoma. Despite utilizing multiple imaging techniques, the patient's complex clinical history complicated the diagnostic process, and the correct diagnosis was established after surgical resection and pathological evaluation. This case highlights the diagnostic pitfalls associated with presumed recurrent cardiac myxomas and underscores the importance of careful pathological assessment and long-term surveillance, even in tumors with low-grade malignant features.

Journal of Cardiothoracic Surgery
Sun Yat-sen University (CN), The First Affiliated Hospital, Sun Yat-sen University (CN)
Zero hunger
Openalex Percentile: Top 8%
Cardiac tumors and thrombi
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