PREFORMULATION STUDIES OF VITAMIN E WITH PHARMACEUTICAL EXCIPIENTS TO DEVELOPMENT CREAM COSMECEUTICAL FOR STRETCH MARKS AS NOVEL DRUG DELIVERY SYSTEMS

Stretch marks, also known as striae distensae (SD), are visible linear scars that form in areas of dermal damage as a result of stretching of the skin. Stretch marks do not represent a serious health issue, but they can have a profound psychological impact on patients, especially on young, healthy women who are frequently affected by this problem. The breasts, upper arms, abdomen, buttocks, and thighs are the area's most frequently affected by this condition. The main objective of the present study was to the preformulation studies were performed to know the development of formulation and evaluation of Vitamin E Creams NDDS for topical application. In the present study that the compatibility was assessed by, FTIR spectroscopy, and preformulation parameters. Results showed that physical mixtures of drug and various excipients such as Vitamin E, and a blend of natural oils were evaluated for preformulation studies parameters. It was concluded that the drug Vitamin E was found to be compatible with various excipients which were selected for the formulation development of the Vitamin E Creams NDDS. Formulation scientist from his experience and knowledge have to significantly in the preformulation study stage and is an important factor in the NDDS (Novel Drug Delivery Systems) product development process.