Corona: A Virtual Mass Spectrometer for the Development of Real-Time Mass Spectrometry Software
Real-time mass spectrometry (RTMS), the process by which mass spectral data are analyzed during acquisition on a mass spectrometer, is an integral part of mass spectrometer development. Particularly within the fields of proteomics and metabolomics, RTMS has evolved to include the creation of third-party software that interfaces with a mass spectrometer to provide novel acquisition methodologies, such as applications that use the IAPI from Thermo Fisher Scientific. Developing and testing RTMS applications with the use of a mass spectrometer is a slow and expensive process that creates a bottleneck in the laboratory. Here, we present Corona, a virtual mass spectrometer for use in RTMS application development independent of a mass spectrometer. RTMS applications developed with IAPI connect to Corona seamlessly and operate exactly the same as if connected to a physical instrument. In this manner, it is possible to rapidly create and test RTMS applications prior to deployment on a mass spectrometer.
Authors
- Judit Villén (ORCID: https://orcid.org/0000-0002-1005-1739)
- William D. Barshop (ORCID: https://orcid.org/0000-0001-9517-2339)
- Jesse D. Canterbury (ORCID: https://orcid.org/0009-0000-5533-1710)
- Michael R. Hoopmann (ORCID: https://orcid.org/0000-0001-7029-7792)
- Christopher D. McGann (ORCID: https://orcid.org/0000-0001-9379-1910)
- Qing Yu (ORCID: https://orcid.org/0000-0003-0468-5353)
- Alexander Hogrebe (ORCID: https://orcid.org/0000-0002-0203-6803)
- Devin K. Schweppe
- Meagan Gadzuk-Shea
Institutions
- University of Massachusetts Chan Medical School (US)
- University of Washington (US)
- Institute for Stem Cell Biology and Regenerative Medicine (IN)
- Brotman Baty Institute (US)
- Thermo Fisher Scientific (United States) (US)
Publication Details
- Journal
- Analytical Chemistry
- Published
- 2026-06-17
- DOI
- https://doi.org/10.1021/acs.analchem.6c01637
- Primary Topic
- Mass Spectrometry Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Pew Charitable Trusts
- W. M. Keck Foundation
- Washington Research Foundation
- European Molecular Biology Organization
- University of Washington
- Andy Hill CARE Fund
- Danmarks Frie Forskningsfond
- National Human Genome Research Institute
- National Cancer Institute
- National Institute of General Medical Sciences