Iron-Catalyzed Aerobic Oxidative Aromatic Coupling of Unprotected Primary Arylamines
A ligand-free, iron-catalyzed aerobic oxidative coupling of unprotected primary arylamines is reported. Utilizing inexpensive FeCl 3 and ambient air as the terminal oxidant, this protocol enables chemoselective ortho–ortho C(sp 2 )–C(sp 2 ) bond formation while bypassing traditional N-protection requirements. The method accommodates regioselective homo- and cross-coupling of primary arylamines, alongside heterocoupling with phenolic substrates, providing a protection-free platform for constructing complex biaryls directly from primary anilines.
Authors
- Xiang Lyu (ORCID: https://orcid.org/0000-0003-1227-8563)
- Changyin Zhao
- Qian Wan (ORCID: https://orcid.org/0000-0001-9243-8939)
- S W
- Xigong Liu
- Lei Liu (ORCID: https://orcid.org/0000-0002-0839-373X)
- Hongbin Liu (ORCID: https://orcid.org/0000-0001-9011-1182)
- Xinning Wang (ORCID: https://orcid.org/0000-0002-3483-5300)
- Jiazheng Wu
Institutions
- Shandong University (CN)
- City University of Hong Kong, Shenzhen Research Institute (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-06-17
- DOI
- https://doi.org/10.1021/acs.orglett.6c01760
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Taishan Scholar Project of Shandong Province
- Shenzhen Fundamental Research Program
- National Key Research and Development Program of China