Phosphodiesterase Type 5 Inhibitor–Induced Relapse of Red Scrotum Syndrome: a Model of Neurovascular Dysregulation
Red scrotum syndrome (RSS) is a rare neurovascular condition causing persistent scrotal erythema and burning pain. We report two cases of RSS relapse triggered by tadalafil, a phosphodiesterase type 5 inhibitor, used for erectile dysfunction. These observations suggest that PDE5 inhibitors may induce or exacerbate RSS through vasodilatory and neurogenic mechanisms, warranting caution in patients with a history of this condition.
Authors
- Charbel Skayem (ORCID: https://orcid.org/0000-0002-4498-0683)
- J.‐N. Dauendorffer (ORCID: https://orcid.org/0000-0001-7763-7323)
- T.A. Duong (ORCID: https://orcid.org/0000-0003-2221-9903)
- Romain Salle (ORCID: https://orcid.org/0000-0003-4411-7289)
Institutions
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Université Paris-Saclay (FR)
- Hôpital Ambroise-Paré (FR)
- Hôpital Saint-Louis (FR)
Publication Details
- Journal
- Clinical and Experimental Dermatology
- Published
- 2026-06-16
- DOI
- https://doi.org/10.1093/ced/llag254
- Primary Topic
- Sexual function and dysfunction studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00