Wearable Biomedical Imaging Electronics for Spatiotemporal Physiological Monitoring: A Cross‐Modality Perspective

ABSTRACT Wearable biomedical imaging electronics are shifting diagnostic imaging from episodic clinical examinations toward continuous spatiotemporal monitoring on soft, skin‐conformal platforms. Achieving clinically credible wearable imaging requires appropriate physical modalities, functional materials, and system‐level design that stabilize biointerface coupling and support reliable physiological inference under dynamic conditions. By enabling non‐invasive visualization of tissue structure and physiological function beyond clinical settings, these systems offer new opportunities for early detection of acute events and longitudinal tracking of chronic disease progression. This Review maps the field from a cross‐modality and clinical task‐oriented perspective, spanning impedance, thermal, radiofrequency, optical, acoustic, and hybrid approaches. We elucidate the physical mechanisms underlying these modalities and compare their performance boundaries, practical constraints, and clinical applicability. We then synthesize recent advances in functional materials, emphasizing material selection and structural optimization for stable skin coupling and scalable arrays. Representative on‐body systems for physiological monitoring and diagnostics are summarized, followed by proposed design principles for modality selection and device‐ or system‐level design in future wearable imaging systems. Finally, we outline a translational roadmap from laboratory demonstrations to deployable healthcare systems. Collectively, these advances position wearable imaging technologies as a foundational layer for continuous, proactive, and personalized healthcare.