The fragility of landmark randomised controlled trials in glaucoma: A systematic review

Objective: Randomized controlled trials (RCTs) form the cornerstone of evidence-based glaucoma care. However, the robustness of statistically significant results in these trials is often unclear. The fragility index (FI) quantifies how easy it is to reverse a significant result, while the fragility [for full text, please go to the a.m. URL]

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Publication Details

Journal
German Medical Science (German Research Foundation)
Published
2026-06-17
DOI
https://doi.org/10.3205/26doc001
Primary Topic
Glaucoma and retinal disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

The fragility of landmark randomised controlled trials in glaucoma: A systematic review

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German Medical Science (German Research Foundation)
Glaucoma and retinal disorders
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The fragility of landmark randomised controlled trials in glaucoma: A systematic review

Sana Hamid, Amar Hamdan, Di Zou, Jeremy Tan, Minsu Jung, Peng Khaw, Abdus Samad Ansari
article en

Abstract

Objective: Randomized controlled trials (RCTs) form the cornerstone of evidence-based glaucoma care. However, the robustness of statistically significant results in these trials is often unclear. The fragility index (FI) quantifies how easy it is to reverse a significant result, while the fragility [for full text, please go to the a.m. URL]

German Medical Science (German Research Foundation)
Moorfields Eye Hospital NHS Foundation Trust (GB), Universität Hamburg (DE), Sydney Hospital (AU), UNSW Sydney (AU), University Medical Center Hamburg-Eppendorf (DE), Moorfields Eye Hospital (GB), University College London (GB)
Openalex Percentile: Top 7%
Glaucoma and retinal disorders
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