Oncologic Outcomes After Liver Transplantation for Unresectable Colorectal Liver Metastases: A Systematic Review and Meta‐Analysis of Proportions
Liver transplantation has emerged as a therapeutic option for highly selected patients with unresectable colorectal liver metastases (CRLM). This review evaluated oncologic and perioperative outcomes in 92 patients who underwent transplantation. One- and 3-year overall survival (OS) were 96.32% and 73.07%, respectively. Disease-free survival (DFS) was lower, with high rates of recurrence. Major complications occurred in 39.36%, and 90-day mortality was 1.03%. Further randomized studies are needed to better define the role of liver transplantation and optimize patient selection criteria.
Authors
- Gloria Barone (ORCID: https://orcid.org/0009-0006-6086-4240)
- Claudia Theis (ORCID: https://orcid.org/0000-0002-1303-298X)
- L Grande (ORCID: https://orcid.org/0000-0001-7115-1218)
- Bernardo Fontel Pompeu (ORCID: https://orcid.org/0009-0009-2960-3810)
- Fernanda Bellotti Formiga (ORCID: https://orcid.org/0000-0001-7225-7145)
- Lucas Monteiro Delgado (ORCID: https://orcid.org/0009-0001-7687-3073)
- Sérgio Mazzola Poli de Figueiredo (ORCID: https://orcid.org/0000-0003-2986-8164)
- Lorrany Ramos Aguiar
- Giuliana Daneluci Melillo
- Alexsander Kuroiwa Bressan
- Laryssa Santana Nakabayashi (ORCID: https://orcid.org/0009-0000-7536-7825)
Institutions
- Universidade Federal de Minas Gerais (BR)
- University of North Carolina at Chapel Hill (US)
- Universidade Municipal de São Caetano do Sul (BR)
- University of Calgary (CA)
- Hospital Heliópolis (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Journal of Surgical Oncology
- Published
- 2026-06-17
- DOI
- https://doi.org/10.1002/jso.70310
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00