Hepatocellular carcinoma muscle and skin metastasis: A case-report

A 55-year-old patient with chronic hepatitis B infection who developed hepatocellular carcinoma. The tumor was managed with primary therapeutic resection. On postoperative follow-up imaging, rising alpha-fetoprotein noted which led into contrast-enhanced MRI of abdomen. On Imaging review, an abdominal wall lesion suspected, which was more conspicuous on the post contrast images. There are several differential diagnosis for these soft tissue lesions which demonstrate many shared imaging characteristics. Musculoskeletal and cutaneous metastases from hepatocellular carcinoma are uncommon, though clinically critical since it changes management. We strongly recommend detailed evaluation of skin and musculoskeletal regions among these patients.

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Publication Details

Journal
Radiology Case Reports
Published
2026-06-17
DOI
https://doi.org/10.1016/j.radcr.2026.05.067
Primary Topic
Cancer Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
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article

Hepatocellular carcinoma muscle and skin metastasis: A case-report

Ali Nosrati Andevari, Mahyar Daskareh, Reihaneh Mortazavi Ardestani, Fatemeh Abbası
Radiology Case Reports
Cancer Diagnosis and Treatment
article

Hepatocellular carcinoma muscle and skin metastasis: A case-report

Ali Nosrati Andevari, Mahyar Daskareh, Reihaneh Mortazavi Ardestani, Fatemeh Abbası
article en

Abstract

A 55-year-old patient with chronic hepatitis B infection who developed hepatocellular carcinoma. The tumor was managed with primary therapeutic resection. On postoperative follow-up imaging, rising alpha-fetoprotein noted which led into contrast-enhanced MRI of abdomen. On Imaging review, an abdominal wall lesion suspected, which was more conspicuous on the post contrast images. There are several differential diagnosis for these soft tissue lesions which demonstrate many shared imaging characteristics. Musculoskeletal and cutaneous metastases from hepatocellular carcinoma are uncommon, though clinically critical since it changes management. We strongly recommend detailed evaluation of skin and musculoskeletal regions among these patients.

Radiology Case ReportsVol. 21(9)
Kerman University of Medical Sciences (IR), Hospital of the University of Pennsylvania (US), Islamic Azad University Tonekabon (IR), Shahid Beheshti University of Medical Sciences (IR), Tehran University of Medical Sciences (IR)
Good health and well-being
Openalex Percentile: Top 12%
Cancer Diagnosis and Treatment
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