Scalable multiplexed machine learning gas sensor chips for food classification

Multiplexed gas sensor arrays combined with machine learning have unlocked previously inaccessible applications for scent-based sensing. Current platforms are limited by overlapping sensing materials with similar compositions, leading to highly correlated responses, or multistep deposition processes that hinder scalability. In this work, we developed a 16-element monolithic chip with fully distinct sensing layers, enabling a truly heterogeneous array. The system consists of highly sensitive carbon nanotube field effect transistors that are functionalized through a single-step microdispensing method compatible with automated pipetting systems. The resulting chip produces characteristic signal patterns in response to object-specific scent profiles and, when combined with machine learning algorithms, can perform automated object identification. We demonstrate the classification of 16 different objects, including food spoilage and nut allergens, with a 92.6% overall prediction accuracy.

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Publication Details

Journal
Science Advances
Published
2026-06-17
DOI
https://doi.org/10.1126/sciadv.aec7965
Primary Topic
Advanced Chemical Sensor Technologies
Type
article
Field-Weighted Citation Impact
0.00

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article

Scalable multiplexed machine learning gas sensor chips for food classification

Xun Liao, Il‐Doo Kim, Carla Bassil, Ali Javey et al.
Science Advances
Advanced Chemical Sensor Technologies
article

Scalable multiplexed machine learning gas sensor chips for food classification

Xun Liao, Il‐Doo Kim, Carla Bassil, Ali Javey, Minhyun Kim, Theodorus Jonathan Wijaya, Kichul Lee, Edward Hester, Divya Krishnan, Inkyu Park, Yifei Zhan
article en

Abstract

Multiplexed gas sensor arrays combined with machine learning have unlocked previously inaccessible applications for scent-based sensing. Current platforms are limited by overlapping sensing materials with similar compositions, leading to highly correlated responses, or multistep deposition processes that hinder scalability. In this work, we developed a 16-element monolithic chip with fully distinct sensing layers, enabling a truly heterogeneous array. The system consists of highly sensitive carbon nanotube field effect transistors that are functionalized through a single-step microdispensing method compatible with automated pipetting systems. The resulting chip produces characteristic signal patterns in response to object-specific scent profiles and, when combined with machine learning algorithms, can perform automated object identification. We demonstrate the classification of 16 different objects, including food spoilage and nut allergens, with a 92.6% overall prediction accuracy.

Science AdvancesVol. 12(25)
Lawrence Berkeley National Laboratory (US), Korea Advanced Institute of Science and Technology (KR), Kavli Energy NanoScience Institute (US), University of California, Berkeley (US)
National Science Foundation, U.S. Department of Energy, Office of Science, Basic Energy Sciences
Zero hunger
Openalex Percentile: Top 12%
Advanced Chemical Sensor Technologies
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