Divergent Synthesis of Quinoxalines and α-Ketothioamides Enabled by Sequential S–S and C–S Bond Cleavage of Bunte Salts

We introduce a divergent and straightforward synthetic approach for the synthesis of quinoxaline and α-ketothioamide derivatives from easily accessible Bunte salts under mild reaction conditions. The transformation proceeds through an unusual and sequential C–S bond cleavage followed by subsequent S–S bond scission. I 2 -mediated conditions enable the synthesis of quinoxalines with 1,2-diamines, while elemental sulfur promotes the synthesis of α-ketothioamides using primary and secondary amines. The protocol proceeds at room temperature under mild conditions, delivers products in good to excellent yields, and demonstrates broad functional group compatibility and scalability.