Swiss cheese Is Essential for Maintaining Spermatogenesis and the Proper Functioning of Biological Barriers in Drosophila

Functional changes in PNPLA6 (Patatin-like phospholipase domain-containing protein 6), caused by gene mutations or inhibition by organophosphates, affect the levels of various phospholipids. In humans, this leads to organophosphorus compound-induced delayed neurotoxicity syndrome (OPIDN) and a number of rare diseases. In this study, we analyze the role of the Swiss cheese gene (sws), an ortholog of PNPLA6, in spermatogenesis in Drosophila melanogaster. We report that the sws1 mutation affects membrane remodeling during spermatid individualization, as well as spermatid coiling during the late stages of spermatogenesis. In addition, the sws1 mutation leads to changes in the transcriptome in the testes of flies. We also demonstrate that sws is required for the proper functioning of important biological barriers in Drosophila.

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Publication Details

Journal
International Journal of Molecular Sciences
Published
2026-06-17
DOI
https://doi.org/10.3390/ijms27125486
Primary Topic
Pesticide Exposure and Toxicity
Type
article
Field-Weighted Citation Impact
0.00

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article

Swiss cheese Is Essential for Maintaining Spermatogenesis and the Proper Functioning of Biological Barriers in Drosophila

Irina V. Ogneva, Artem E. Komissarov, Elena V. Ryabova, Elizaveta E. Slepneva et al.
International Journal of Molecular Sciences
Pesticide Exposure and Toxicity
article

Swiss cheese Is Essential for Maintaining Spermatogenesis and the Proper Functioning of Biological Barriers in Drosophila

Irina V. Ogneva, Artem E. Komissarov, Elena V. Ryabova, Elizaveta E. Slepneva, С. В. Саранцева, Evgeniia M. Latypova, Ekaterina A. Ivanova, Natalia V. Dorogova, Elena U. Bolobolova
article en

Abstract

Functional changes in PNPLA6 (Patatin-like phospholipase domain-containing protein 6), caused by gene mutations or inhibition by organophosphates, affect the levels of various phospholipids. In humans, this leads to organophosphorus compound-induced delayed neurotoxicity syndrome (OPIDN) and a number of rare diseases. In this study, we analyze the role of the Swiss cheese gene (sws), an ortholog of PNPLA6, in spermatogenesis in Drosophila melanogaster. We report that the sws1 mutation affects membrane remodeling during spermatid individualization, as well as spermatid coiling during the late stages of spermatogenesis. In addition, the sws1 mutation leads to changes in the transcriptome in the testes of flies. We also demonstrate that sws is required for the proper functioning of important biological barriers in Drosophila.

International Journal of Molecular SciencesVol. 27(12)
Kurchatov Institute (RU), Institute of Biomedical Problems (RU), Institute of Cytology and Genetics (RU), Siberian Branch of the Russian Academy of Sciences (RU), Petersburg Nuclear Physics Institute (RU)
Siberian Branch, Russian Academy of Sciences, Ministry of Education and Science of the Russian Federation, Russian Science Foundation, Ministry of Science and Higher Education of the Russian Federation
Openalex Percentile: Top 9%
Pesticide Exposure and Toxicity
DOIOpen Access PDFOpenAlex
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