Uncommon Tumor, Unusual Site, and Unconventional Behavior: Report of a Gastric Composite Gangliocytoma/Neuroma and Neuroendocrine Tumor (CoGNET) With Metastases

came an important distinction between epithelial and non-epithelial neoplasms, and the possibility of composite tumor in certain organs, including the duodenum, the spine and the middle ear. In particular, the formerly termed gangliocytic paraganglioma of the duodenum has been renamed as "composite gangliocytoma/neuroma and neuroendocrine tumor (CoGNET)." We present an unusual CoGNET arising in the stomach, displaying distinctive histomorphologies in primary tumor and metastases. Additionally, we discuss diagnostic pitfalls and highlight the importance of recognizing the combined features that can be seen in this rare, potentially malignant, entity.

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Publication Details

Journal
International Journal of Surgical Pathology
Published
2026-06-16
DOI
https://doi.org/10.1177/10668969261457873
Primary Topic
Adrenal and Paraganglionic Tumors
Type
article
Field-Weighted Citation Impact
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article

Uncommon Tumor, Unusual Site, and Unconventional Behavior: Report of a Gastric Composite Gangliocytoma/Neuroma and Neuroendocrine Tumor (CoGNET) With Metastases

Pooja Navale, Nikolaos Trikalinos, Alicia Dessain, Vikas Prasad
International Journal of Surgical Pathology
Adrenal and Paraganglionic Tumors
article

Uncommon Tumor, Unusual Site, and Unconventional Behavior: Report of a Gastric Composite Gangliocytoma/Neuroma and Neuroendocrine Tumor (CoGNET) With Metastases

Pooja Navale, Nikolaos Trikalinos, Alicia Dessain, Vikas Prasad
article en

Abstract

came an important distinction between epithelial and non-epithelial neoplasms, and the possibility of composite tumor in certain organs, including the duodenum, the spine and the middle ear. In particular, the formerly termed gangliocytic paraganglioma of the duodenum has been renamed as "composite gangliocytoma/neuroma and neuroendocrine tumor (CoGNET)." We present an unusual CoGNET arising in the stomach, displaying distinctive histomorphologies in primary tumor and metastases. Additionally, we discuss diagnostic pitfalls and highlight the importance of recognizing the combined features that can be seen in this rare, potentially malignant, entity.

International Journal of Surgical Pathology
Washington University in St. Louis (US), University of Missouri Hospital (US), Cooper University Health Care (US)
Good health and well-being
Openalex Percentile: Top 6%
Adrenal and Paraganglionic Tumors
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