A Safe Approach to <i>meta</i> ‐Fluorinated Pyridines
ABSTRACT Since 1947, the Balz–Schiemann reaction has remained the most popular method for the synthesis of meta ‐fluoropyridines. The method involves dangerous pyridyl diazonium salts and has led to numerous documented explosions. A safe alternative to meta ‐fluoropyridines has now been developed on the basis of a 1,3‐disconnection strategy.
Authors
- Pavel K. Mykhailiuk (ORCID: https://orcid.org/0000-0003-1821-9011)
- Vadym Sham (ORCID: https://orcid.org/0000-0003-0059-4876)
- Аndrii Kysil
- Bohdan Dansberg
- Oleksandra Rushchak
- Tetyana Yegorova
Institutions
- Taras Shevchenko National University of Kyiv (UA)
- Institute of Organic Chemistry (UA)
- Enamine (Ukraine) (UA)
Publication Details
- Journal
- Angewandte Chemie
- Published
- 2026-06-16
- DOI
- https://doi.org/10.1002/ange.7155694
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00