Regioselective gold-catalyzed addition of phenols, alcohols and carboxylic acids to 2,2,2-trifluoroethyl-substituted alkynes
The gold-catalyzed addition of phenols, alcohols, and carboxylic acids to 2,2,2-trifluoroethyl-substituted alkynes is reported. The reaction is highly regioselective, once again illustrating the strong directing effect of the trifluoromethyl group in gold-catalyzed additions to alkynes through its inductive influence.
Authors
- Raphaël Gauthier
- Nikolaos V. Tzouras (ORCID: https://orcid.org/0000-0003-1718-0207)
- Steven P. Nolan (ORCID: https://orcid.org/0000-0001-9024-2035)
- Jean‐François Paquin (ORCID: https://orcid.org/0000-0003-2412-3083)
- Raphaël Pronovost
Institutions
- Ghent University (BE)
- Université Laval (CA)
Publication Details
- Journal
- Journal of Fluorine Chemistry
- Published
- 2026-06-16
- DOI
- https://doi.org/10.1016/j.jfluchem.2026.110589
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Université Laval
- Centre in Green Chemistry and Catalysis
- Fonds Wetenschappelijk Onderzoek
- Natural Sciences and Engineering Research Council of Canada