Crohn Disease Presenting as Vaginal Discharge in a Patient With Systemic Lupus Erythematosus

Crohn disease (CD), a subtype of inflammatory bowel disease, may be complicated by extraintestinal manifestations. Although cutaneous findings are among the most frequent, metastatic Crohn disease (MCD), defined as mucocutaneous CD at sites noncontiguous with the gastrointestinal tract, is rare. Children with MCD are more likely than adults to develop genital inflammation. Case reports describe the vulva, scrotum, and penis as common locations of involvement in children with genital MCD. We report a case of a pediatric patient with systemic lupus erythematosus who developed vaginal discharge as a presenting symptom of MCD in the absence of an anorectal-vaginal fistula. We describe an unusual combination of clinical features and intend to improve awareness of uncommon extraintestinal manifestations of CD.

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Journal
PEDIATRICS
Published
2026-06-17
DOI
https://doi.org/10.1542/peds.2025-073979
Primary Topic
Autoimmune and Inflammatory Disorders
Type
article
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article

Crohn Disease Presenting as Vaginal Discharge in a Patient With Systemic Lupus Erythematosus

Yvonne E. Chiu, James J. Nocton, Lisa M. Arkin, Christine M. Seroogy et al.
PEDIATRICS
Autoimmune and Inflammatory Disorders
article

Crohn Disease Presenting as Vaginal Discharge in a Patient With Systemic Lupus Erythematosus

Yvonne E. Chiu, James J. Nocton, Lisa M. Arkin, Christine M. Seroogy, Kara Young, Alexa G. Ries, Joann Samalik, Jessica Francis
article en

Abstract

Crohn disease (CD), a subtype of inflammatory bowel disease, may be complicated by extraintestinal manifestations. Although cutaneous findings are among the most frequent, metastatic Crohn disease (MCD), defined as mucocutaneous CD at sites noncontiguous with the gastrointestinal tract, is rare. Children with MCD are more likely than adults to develop genital inflammation. Case reports describe the vulva, scrotum, and penis as common locations of involvement in children with genital MCD. We report a case of a pediatric patient with systemic lupus erythematosus who developed vaginal discharge as a presenting symptom of MCD in the absence of an anorectal-vaginal fistula. We describe an unusual combination of clinical features and intend to improve awareness of uncommon extraintestinal manifestations of CD.

PEDIATRICS
University of Wisconsin–Madison (US), Medical College of Wisconsin (US), Wisconsin Division of Public Health (US)
Good health and well-being
Openalex Percentile: Top 8%
Autoimmune and Inflammatory Disorders
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