Redefining radiotherapy: the gut as an active target in Immuno-Oncology
Low-dose intestinal irradiation challenges the long-standing view of the gut as a radiation-sensitive organ to avoid. Clinical and mechanistic data suggest that targeted exposure of the small intestine within a 1 to 3 Gy window can remodel the microbiome and enhance systemic antitumor immunity.
Authors
- Antonin Lévy (ORCID: https://orcid.org/0000-0003-4798-8899)
- Eric C Deutsch (ORCID: https://orcid.org/0000-0002-8223-3697)
- Laurence Zitvogel (ORCID: https://orcid.org/0000-0003-1596-0998)
Institutions
- Institut Gustave Roussy (FR)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2026-06-16
- DOI
- https://doi.org/10.1158/1078-0432.ccr-26-1177
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 0.00