A Safe Approach to <i>meta</i> ‐Fluorinated Pyridines
Since 1947, the Balz-Schiemann reaction has remained the most popular method for the synthesis of meta-fluoropyridines. The method involves dangerous pyridyl diazonium salts and has led to numerous documented explosions. A safe alternative to meta-fluoropyridines has now been developed on the basis of a 1,3-disconnection strategy.
Authors
- Pavel K. Mykhailiuk (ORCID: https://orcid.org/0000-0003-1821-9011)
- Vadym Sham (ORCID: https://orcid.org/0000-0003-0059-4876)
- Аndrii Kysil
- Bohdan Dansberg
- Oleksandra Rushchak
- Tetyana Yegorova
Institutions
- Taras Shevchenko National University of Kyiv (UA)
- Institute of Organic Chemistry (UA)
- Enamine (Ukraine) (UA)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2026-06-16
- DOI
- https://doi.org/10.1002/anie.7155694
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00