Breast cancer incidence and mortality in population studies of radiation exposure: systematic review and meta-analysis

Abstract Background While breast cancer risk from high-dose ionising radiation is known, uncertainties remain about risks at lower doses and risk-modifying factors. We conducted a systematic review and meta-analysis of publications on radiation-associated risk of breast cancer in women. Methods We included studies published in 2005–2022 that assessed breast cancer incidence or mortality in women exposed to ionising radiation. Risk of bias was evaluated. Random-effects meta-analyses estimated excess relative risks per gray (ERR/Gy). Results Of the 3522 articles screened, 106 met the inclusion criteria; 40 studies provided 44 ERR/Gy estimates. Overall, radiation exposure was associated with increased breast cancer risk (ERR/Gy = 0.56, 95% CI: 0.29–0.83). Between-study heterogeneity ( I 2 = 95%) was substantially reduced in subgroup analyses, reaching 5% in low-dose-rate studies. Higher summary ERRs were observed for high dose-rate exposures, moderate (1–5 Gy) doses, childhood exposures, and attained age over 55. Lower but significantly increased risks were estimated for other subgroups and exposure scenarios. Conclusions Radiation exposure was associated with a significantly increased risk of breast cancer among women, particularly following high dose-rates, moderate doses, childhood exposures, and older attained age. PROSPERO registration: CRD42021260610.