The KRASG12D Inhibitor Pipeline Grows

At this year's ASCO Annual Meeting, investigators also presented encouraging early clinical data for several KRASG12D-selective inhibitors, including RNK08594, GFH375, and DN022150, suggesting that this type of drug could play a role in the treatment of several solid tumors, such as pancreatic ductal adenocarcinoma and non-small cell lung cancer.

Publication Details

Journal
Cancer Discovery
Published
2026-06-16
DOI
https://doi.org/10.1158/2159-8290.cd-nw2026-0069
Primary Topic
Protein Kinase Regulation and GTPase Signaling
Type
article
Field-Weighted Citation Impact
0.00
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article

The KRASG12D Inhibitor Pipeline Grows

Cancer Discovery
Protein Kinase Regulation and GTPase Signaling
article

The KRASG12D Inhibitor Pipeline Grows

article en

Abstract

At this year's ASCO Annual Meeting, investigators also presented encouraging early clinical data for several KRASG12D-selective inhibitors, including RNK08594, GFH375, and DN022150, suggesting that this type of drug could play a role in the treatment of several solid tumors, such as pancreatic ductal adenocarcinoma and non-small cell lung cancer.

Cancer Discovery
Good health and well-being
Openalex Percentile: Top 12%
Protein Kinase Regulation and GTPase Signaling
DOISourceOpenAlex
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The KRASG12D Inhibitor Pipeline Grows · Cancer Discovery (2026) | TGRS Research Map | TGRS