Hepatic Inflammatory Pseudotumor Presenting as FDG-avid Liver Lesions in a Prostate Cancer Patient

A 70-year-old man with prostate cancer underwent contrast-enhanced CT for lesion characterization, which revealed two newly detected hepatic lesions suspicious for metastasis. The prostate-specific antigen level remained below the threshold for biochemical recurrence, whereas C-reactive protein was elevated. 18F-FDG PET/CT was performed for metabolic characterization and whole-body evaluation, demonstrating heterogeneous increased uptake in both lesions. On the basis of the CT findings and FDG hypermetabolism, liver-confined metastatic disease was suspected, and surgical resection was performed. Histopathology unexpectedly revealed a hepatic inflammatory pseudotumor.