Post-Procedural CT Comparison of Predicted and Actual Neo-LVOT After One-Session Double Valve-in-Valve Implantation: A Case Report

Abstract Background Left ventricular outflow tract (LVOT) obstruction is a serious complication of transcatheter mitral valve replacement and mitral valve-in-valve (ViV) procedures. CT-based virtual valve implantation predicts the neo-LVOT area, but it assumes idealized seating and may not fully reflect procedural interaction during double-valve intervention. Case summary A 74-year-old woman with degenerated surgical mitral and aortic bioprostheses presented with NYHA class IV heart failure. Full-cycle ECG-gated 4D-CT identified the minimum predicted neo-LVOT at 43% of the R-R interval (300.9 mm2). A one-session transapical double ViV procedure was performed. The aortic ViV was performed first because CT simulation showed that the aortic balloon would expand between the two strut posts of the surgical mitral prosthesis; implanting the mitral valve first could have exposed the newly deployed mitral prosthesis to compression during subsequent aortic balloon expansion. Post-procedural 4D-CT, evaluated using the same workflow and compared at 43%, showed a neo-LVOT area of 280.6 mm2, a 20.3 mm2 reduction, with approximately 1.2 mm asymmetric ventricular protrusion of the mitral prosthesis. Echocardiography showed normal valve-in-valve function and no haemodynamic LVOT obstruction. Discussion This case demonstrates that CT-based planning correctly identified procedural feasibility, while post-procedural CT revealed measurable geometric variability. The finding remained well above high-risk thresholds and should be interpreted as a hypothesis-generating geometric observation rather than clinically significant obstruction.