The quiet brain injury in thrombotic thrombocytopenic purpura: Are we missing the warning signs?

Silent cerebral infarctions (SCIs) are present in patients with a diagnosis of immune-mediated thrombotic thrombocytopenic purpura (iTTP) at a younger age and with a higher prevalence than in the general population. Prior history of stroke, cardiovascular disease and diabetes are risk factors for SCI in patients with a prior diagnosis of iTTP. Commentary on: Javed et al. Risk factors for silent cerebral infarction in immune-mediated thrombotic thrombocytopenic survivors. Br J Haematol 2026;208(2):654-660.