Divergent PET Tracer Avidity in Synchronous Sarcomatoid Carcinoma With Osteosarcomatous Differentiation and Adenocarcinoma of the Prostate
A 76-year-old man with mildly elevated prostate-specific antigen (PSA, 5.44ng/mL) and a PI-RADS 5 lesion on multiparametric MRI underwent dual-tracer PET/CT. 68Ga-PSMA PET/CT revealed focal intense uptake in one prostatic lobe, while 18F-FDG PET/CT demonstrated avid uptake in the contralateral lobe. Histopathology confirmed synchronous high-grade prostatic adenocarcinoma (Gleason 9) and sarcomatoid carcinoma with osteosarcomatous differentiation. This discordant dual-tracer pattern highlights the complementary role of PSMA and FDG PET/CT in detecting molecularly divergent synchronous prostatic malignancies.
Authors
- Eray Alper (ORCID: https://orcid.org/0000-0002-7151-3650)
- Efrah Ahmed Ibrahim
Institutions
- Bursa Uludağ Üni̇versi̇tesi̇ (TR)
Publication Details
- Journal
- Clinical Nuclear Medicine
- Published
- 2026-06-16
- DOI
- https://doi.org/10.1097/rlu.0000000000006576
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00