Further Validation and Threshold Determination of Brazilian-Portuguese Version of the CU-Q2oL Questionnaire
Chronic spontaneous urticaria markedly affects quality of life, and this study evaluated the Brazilian-Portuguese CU-Q2oL in 173 CSU patients, examining its validity, correlations with established patient-reported outcomes, and clinically meaningful severity cut-offs. CU-Q2oL scores correlated strongly with DLQI, moderately with UAS7, inversely with UCT, and a data-driven four-tier severity model showed excellent discriminatory performance. These findings support the CU-Q2oL as a valid QoL instrument in CSU and suggest that the four-tier scoring system may improve clinical stratification and treatment planning.
Authors
- Diogo Mota (ORCID: https://orcid.org/0000-0002-7812-4033)
- Alice Horta
- João Marcelino (ORCID: https://orcid.org/0000-0001-8462-8847)
- Felix Aulenbacher
- Ana Todo-Bom
- Frederico Regateiro
- Martin Metz
- Ruben Ferreira
- Joana Guimarães
- Elza Tomaz
- Leonor Leão
- Helena Pereira
Institutions
- Hospitais da Universidade de Coimbra (PT)
- Hospital de São João (PT)
- Humboldt-Universität zu Berlin (DE)
- Instituto Superior de Espinho (PT)
- Osso (PT)
- Fraunhofer Institute for Translational Medicine and Pharmacology (DE)
- Hospital de São Bernardo (PT)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Hospital Central de las Fuerzas Armadas (UY)
- University of Coimbra (PT)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2026-06-16
- DOI
- https://doi.org/10.1093/bjd/ljag242
- Primary Topic
- Urticaria and Related Conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00