Co-Delivery of Chemo and Immune Drugs by Prussian Blue Nanocubes for Combinational Therapy and <i>T</i> <sub>1</sub> − <i>T</i> <sub>2</sub> W MR Imaging of MDA-MB-231

) than commercial contrast agents (MAGNEVIST, GADOVIST, PROHANCE, etc.), indicating its potency as a dual-mode contrast agent for magnetic resonance imaging (MRI). We have also validated a drug co-loading mechanism through a series of molecular dynamics simulations, followed by experimental measurements. Importantly, in vivo studies using a xenograft mouse model demonstrate significant tumor growth inhibition, with the nanoformulation + NIR irradiated group showing the most effective anti-tumor outcome with negligible hepatic, renal, and cardiac toxicities. Taken together, it may be stated that the doxorubicin/JQ1 co-loaded PBNCs might be a potential next-generation anti-TNBC theranostic agent, which combines dual-mode MRI capability and combination therapy with reduced side effects.

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Publication Details

Journal
ACS Applied Bio Materials
Published
2026-06-16
DOI
https://doi.org/10.1021/acsabm.6c00073
Primary Topic
Nanoparticle-Based Drug Delivery
Type
article
Field-Weighted Citation Impact
0.00

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article

Co-Delivery of Chemo and Immune Drugs by Prussian Blue Nanocubes for Combinational Therapy and T 1 − T 2 W MR Imaging of MDA-MB-231

Chandan Kumar Ghosh, Sourav Kumar Nandi, Pratik Chakraborty, Saikat Dewanjee et al.
ACS Applied Bio Materials
Nanoparticle-Based Drug Delivery
article

Co-Delivery of Chemo and Immune Drugs by Prussian Blue Nanocubes for Combinational Therapy and T 1 − T 2 W MR Imaging of MDA-MB-231

Chandan Kumar Ghosh, Sourav Kumar Nandi, Pratik Chakraborty, Saikat Dewanjee, Panchanan Sahoo, Kamalesh Roy, Mandira Das, Barun Kumar Maity, Pulak Jana, Sudip Kundu
article en

Abstract

) than commercial contrast agents (MAGNEVIST, GADOVIST, PROHANCE, etc.), indicating its potency as a dual-mode contrast agent for magnetic resonance imaging (MRI). We have also validated a drug co-loading mechanism through a series of molecular dynamics simulations, followed by experimental measurements. Importantly, in vivo studies using a xenograft mouse model demonstrate significant tumor growth inhibition, with the nanoformulation + NIR irradiated group showing the most effective anti-tumor outcome with negligible hepatic, renal, and cardiac toxicities. Taken together, it may be stated that the doxorubicin/JQ1 co-loaded PBNCs might be a potential next-generation anti-TNBC theranostic agent, which combines dual-mode MRI capability and combination therapy with reduced side effects.

ACS Applied Bio Materials
Saha Institute of Nuclear Physics (IN), Indian Institute of Chemical Biology (IN), Jadavpur University (IN), Advanced Pharma (US), Centre de Biologie Structurale (FR), National Institute of Cholera and Enteric Diseases (IN), Max Planck Institute for Biophysical Chemistry (DE), Academy of Scientific and Innovative Research (IN)
Indian Council of Medical Research, Council of Scientific and Industrial Research, India
Good health and well-being
Openalex Percentile: Top 13%
Nanoparticle-Based Drug Delivery
DOISourceOpenAlex
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